Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez IS
PROVIDER: S-EPMC3017601 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Fernández Israel S IS Yamashita Akio A Arias-Palomo Ernesto E Bamba Yumi Y Bartolomé Ruben A RA Canales M Angeles MA Teixidó Joaquín J Ohno Shigeo S Llorca Oscar O
Nucleic acids research 20100903 1
SMG-9 is part of a protein kinase complex, SMG1C, which consists of the SMG-1 kinase, SMG-8 and SMG-9. SMG1C mediated phosphorylation of Upf1 triggers nonsense-mediated mRNA decay (NMD), a eukaryotic surveillance pathway that detects and targets for degradation mRNAs harboring premature translation termination codons. Here, we have characterized SMG-9, showing that it comprises an N-terminal 180 residue intrinsically disordered region (IDR) followed by a well-folded C-terminal domain. Both domai ...[more]