New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
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ABSTRACT:
SUBMITTER: Dupuis J
PROVIDER: S-EPMC3018764 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Dupuis Josée J Langenberg Claudia C Prokopenko Inga I Saxena Richa R Soranzo Nicole N Jackson Anne U AU Wheeler Eleanor E Glazer Nicole L NL Bouatia-Naji Nabila N Gloyn Anna L AL Lindgren Cecilia M CM Mägi Reedik R Morris Andrew P AP Randall Joshua J Johnson Toby T Elliott Paul P Rybin Denis D Thorleifsson Gudmar G Steinthorsdottir Valgerdur V Henneman Peter P Grallert Harald H Dehghan Abbas A Hottenga Jouke Jan JJ Franklin Christopher S CS Navarro Pau P Song Kijoung K Goel Anuj A Perry John R B JR Egan Josephine M JM Lajunen Taina T Grarup Niels N Sparsø Thomas T Doney Alex A Voight Benjamin F BF Stringham Heather M HM Li Man M Kanoni Stavroula S Shrader Peter P Cavalcanti-Proença Christine C Kumari Meena M Qi Lu L Timpson Nicholas J NJ Gieger Christian C Zabena Carina C Rocheleau Ghislain G Ingelsson Erik E An Ping P O'Connell Jeffrey J Luan Jian'an J Elliott Amanda A McCarroll Steven A SA Payne Felicity F Roccasecca Rosa Maria RM Pattou François F Sethupathy Praveen P Ardlie Kristin K Ariyurek Yavuz Y Balkau Beverley B Barter Philip P Beilby John P JP Ben-Shlomo Yoav Y Benediktsson Rafn R Bennett Amanda J AJ Bergmann Sven S Bochud Murielle M Boerwinkle Eric E Bonnefond Amélie A Bonnycastle Lori L LL Borch-Johnsen Knut K Böttcher Yvonne Y Brunner Eric E Bumpstead Suzannah J SJ Charpentier Guillaume G Chen Yii-Der Ida YD Chines Peter P Clarke Robert R Coin Lachlan J M LJ Cooper Matthew N MN Cornelis Marilyn M Crawford Gabe G Crisponi Laura L Day Ian N M IN de Geus Eco J C EJ Delplanque Jerome J Dina Christian C Erdos Michael R MR Fedson Annette C AC Fischer-Rosinsky Antje A Forouhi Nita G NG Fox Caroline S CS Frants Rune R Franzosi Maria Grazia MG Galan Pilar P Goodarzi Mark O MO Graessler Jürgen J Groves Christopher J CJ Grundy Scott S Gwilliam Rhian R Gyllensten Ulf U Hadjadj Samy S Hallmans Göran G Hammond Naomi N Han Xijing X Hartikainen Anna-Liisa AL Hassanali Neelam N Hayward Caroline C Heath Simon C SC Hercberg Serge S Herder Christian C Hicks Andrew A AA Hillman David R DR Hingorani Aroon D AD Hofman Albert A Hui Jennie J Hung Joe J Isomaa Bo B Johnson Paul R V PR Jørgensen Torben T Jula Antti A Kaakinen Marika M Kaprio Jaakko J Kesaniemi Y Antero YA Kivimaki Mika M Knight Beatrice B Koskinen Seppo S Kovacs Peter P Kyvik Kirsten Ohm KO Lathrop G Mark GM Lawlor Debbie A DA Le Bacquer Olivier O Lecoeur Cécile C Li Yun Y Lyssenko Valeriya V Mahley Robert R Mangino Massimo M Manning Alisa K AK Martínez-Larrad María Teresa MT McAteer Jarred B JB McCulloch Laura J LJ McPherson Ruth R Meisinger Christa C Melzer David D Meyre David D Mitchell Braxton D BD Morken Mario A MA Mukherjee Sutapa S Naitza Silvia S Narisu Narisu N Neville Matthew J MJ Oostra Ben A BA Orrù Marco M Pakyz Ruth R Palmer Colin N A CN Paolisso Giuseppe G Pattaro Cristian C Pearson Daniel D Peden John F JF Pedersen Nancy L NL Perola Markus M Pfeiffer Andreas F H AF Pichler Irene I Polasek Ozren O Posthuma Danielle D Potter Simon C SC Pouta Anneli A Province Michael A MA Psaty Bruce M BM Rathmann Wolfgang W Rayner Nigel W NW Rice Kenneth K Ripatti Samuli S Rivadeneira Fernando F Roden Michael M Rolandsson Olov O Sandbaek Annelli A Sandhu Manjinder M Sanna Serena S Sayer Avan Aihie AA Scheet Paul P Scott Laura J LJ Seedorf Udo U Sharp Stephen J SJ Shields Beverley B Sigurethsson Gunnar G Sijbrands Eric J G EJ Silveira Angela A Simpson Laila L Singleton Andrew A Smith Nicholas L NL Sovio Ulla U Swift Amy A Syddall Holly H Syvänen Ann-Christine AC Tanaka Toshiko T Thorand Barbara B Tichet Jean J Tönjes Anke A Tuomi Tiinamaija T Uitterlinden André G AG van Dijk Ko Willems KW van Hoek Mandy M Varma Dhiraj D Visvikis-Siest Sophie S Vitart Veronique V Vogelzangs Nicole N Waeber Gérard G Wagner Peter J PJ Walley Andrew A Walters G Bragi GB Ward Kim L KL Watkins Hugh H Weedon Michael N MN Wild Sarah H SH Willemsen Gonneke G Willemsen Gonneke G Witteman Jaqueline C M JC Yarnell John W G JW Zeggini Eleftheria E Zelenika Diana D Zethelius Björn B Zhai Guangju G Zhao Jing Hua JH Zillikens M Carola MC Borecki Ingrid B IB Loos Ruth J F RJ Meneton Pierre P Magnusson Patrik K E PK Nathan David M DM Williams Gordon H GH Hattersley Andrew T AT Silander Kaisa K Salomaa Veikko V Smith George Davey GD Bornstein Stefan R SR Schwarz Peter P Spranger Joachim J Karpe Fredrik F Shuldiner Alan R AR Cooper Cyrus C Dedoussis George V GV Serrano-Ríos Manuel M Morris Andrew D AD Lind Lars L Palmer Lyle J LJ Hu Frank B FB Franks Paul W PW Ebrahim Shah S Marmot Michael M Kao W H Linda WH Pankow James S JS Sampson Michael J MJ Kuusisto Johanna J Laakso Markku M Hansen Torben T Pedersen Oluf O Pramstaller Peter Paul PP Wichmann H Erich HE Illig Thomas T Rudan Igor I Wright Alan F AF Stumvoll Michael M Campbell Harry H Wilson James F JF Bergman Richard N RN Buchanan Thomas A TA Collins Francis S FS Mohlke Karen L KL Tuomilehto Jaakko J Valle Timo T TT Altshuler David D Rotter Jerome I JI Siscovick David S DS Penninx Brenda W J H BW Boomsma Dorret I DI Deloukas Panos P Spector Timothy D TD Frayling Timothy M TM Ferrucci Luigi L Kong Augustine A Thorsteinsdottir Unnur U Stefansson Kari K van Duijn Cornelia M CM Aulchenko Yurii S YS Cao Antonio A Scuteri Angelo A Schlessinger David D Uda Manuela M Ruokonen Aimo A Jarvelin Marjo-Riitta MR Waterworth Dawn M DM Vollenweider Peter P Peltonen Leena L Mooser Vincent V Abecasis Goncalo R GR Wareham Nicholas J NJ Sladek Robert R Froguel Philippe P Watanabe Richard M RM Meigs James B JB Groop Leif L Boehnke Michael M McCarthy Mark I MI Florez Jose C JC Barroso Inês I
Nature genetics 20100117 2
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin a ...[more]