Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
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ABSTRACT:
SUBMITTER: Lagou V
PROVIDER: S-EPMC7785747 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou Vasiliki V Mägi Reedik R Hottenga Jouke- Jan JJ Grallert Harald H Perry John R B JRB Bouatia-Naji Nabila N Marullo Letizia L Rybin Denis D Jansen Rick R Min Josine L JL Dimas Antigone S AS Ulrich Anna A Zudina Liudmila L Gådin Jesper R JR Jiang Longda L Faggian Alessia A Bonnefond Amélie A Fadista Joao J Stathopoulou Maria G MG Isaacs Aaron A Willems Sara M SM Navarro Pau P Tanaka Toshiko T Jackson Anne U AU Montasser May E ME O'Connell Jeff R JR Bielak Lawrence F LF Webster Rebecca J RJ Saxena Richa R Stafford Jeanette M JM Pourcain Beate St BS Timpson Nicholas J NJ Salo Perttu P Shin So-Youn SY Amin Najaf N Smith Albert V AV Li Guo G Verweij Niek N Goel Anuj A Ford Ian I Johnson Paul C D PCD Johnson Toby T Kapur Karen K Thorleifsson Gudmar G Strawbridge Rona J RJ Rasmussen-Torvik Laura J LJ Esko Tõnu T Mihailov Evelin E Fall Tove T Fraser Ross M RM Mahajan Anubha A Kanoni Stavroula S Giedraitis Vilmantas V Kleber Marcus E ME Silbernagel Günther G Meyer Julia J Müller-Nurasyid Martina M Ganna Andrea A Sarin Antti-Pekka AP Yengo Loic L Shungin Dmitry D Luan Jian'an J Horikoshi Momoko M An Ping P Sanna Serena S Boettcher Yvonne Y Rayner N William NW Nolte Ilja M IM Zemunik Tatijana T Iperen Erik van EV Kovacs Peter P Hastie Nicholas D ND Wild Sarah H SH McLachlan Stela S Campbell Susan S Polasek Ozren O Carlson Olga O Egan Josephine J Kiess Wieland W Willemsen Gonneke G Kuusisto Johanna J Laakso Markku M Dimitriou Maria M Hicks Andrew A AA Rauramaa Rainer R Bandinelli Stefania S Thorand Barbara B Liu Yongmei Y Miljkovic Iva I Lind Lars L Doney Alex A Perola Markus M Hingorani Aroon A Kivimaki Mika M Kumari Meena M Bennett Amanda J AJ Groves Christopher J CJ Herder Christian C Koistinen Heikki A HA Kinnunen Leena L Faire Ulf de U Bakker Stephan J L SJL Uusitupa Matti M Palmer Colin N A CNA Jukema J Wouter JW Sattar Naveed N Pouta Anneli A Snieder Harold H Boerwinkle Eric E Pankow James S JS Magnusson Patrik K PK Krus Ulrika U Scapoli Chiara C de Geus Eco J C N EJCN Blüher Matthias M Wolffenbuttel Bruce H R BHR Province Michael A MA Abecasis Goncalo R GR Meigs James B JB Hovingh G Kees GK Lindström Jaana J Wilson James F JF Wright Alan F AF Dedoussis George V GV Bornstein Stefan R SR Schwarz Peter E H PEH Tönjes Anke A Winkelmann Bernhard R BR Boehm Bernhard O BO März Winfried W Metspalu Andres A Price Jackie F JF Deloukas Panos P Körner Antje A Lakka Timo A TA Keinanen-Kiukaanniemi Sirkka M SM Saaristo Timo E TE Bergman Richard N RN Tuomilehto Jaakko J Wareham Nicholas J NJ Langenberg Claudia C Männistö Satu S Franks Paul W PW Hayward Caroline C Vitart Veronique V Kaprio Jaakko J Visvikis-Siest Sophie S Balkau Beverley B Altshuler David D Rudan Igor I Stumvoll Michael M Campbell Harry H van Duijn Cornelia M CM Gieger Christian C Illig Thomas T Ferrucci Luigi L Pedersen Nancy L NL Pramstaller Peter P PP Boehnke Michael M Frayling Timothy M TM Shuldiner Alan R AR Peyser Patricia A PA Kardia Sharon L R SLR Palmer Lyle J LJ Penninx Brenda W BW Meneton Pierre P Harris Tamara B TB Navis Gerjan G Harst Pim van der PV Smith George Davey GD Forouhi Nita G NG Loos Ruth J F RJF Salomaa Veikko V Soranzo Nicole N Boomsma Dorret I DI Groop Leif L Tuomi Tiinamaija T Hofman Albert A Munroe Patricia B PB Gudnason Vilmundur V Siscovick David S DS Watkins Hugh H Lecoeur Cecile C Vollenweider Peter P Franco-Cereceda Anders A Eriksson Per P Jarvelin Marjo-Riitta MR Stefansson Kari K Hamsten Anders A Nicholson George G Karpe Fredrik F Dermitzakis Emmanouil T ET Lindgren Cecilia M CM McCarthy Mark I MI Froguel Philippe P Kaakinen Marika A MA Lyssenko Valeriya V Watanabe Richard M RM Ingelsson Erik E Florez Jose C JC Dupuis Josée J Barroso Inês I Morris Andrew P AP Prokopenko Inga I
Nature communications 20210105 1
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association stu ...[more]
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