Common variants in P2RY11 are associated with narcolepsy.
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ABSTRACT:
SUBMITTER: Kornum BR
PROVIDER: S-EPMC3019286 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Common variants in P2RY11 are associated with narcolepsy.
Kornum Birgitte R BR Kawashima Minae M Faraco Juliette J Lin Ling L Rico Thomas J TJ Hesselson Stephanie S Axtell Robert C RC Kuipers Hedwich H Weiner Karin K Hamacher Alexandra A Kassack Matthias U MU Han Fang F Knudsen Stine S Li Jing J Dong Xiaosong X Winkelmann Juliane J Plazzi Giuseppe G Nevsimalova Sona S Hong Seung-Chul SC Honda Yutaka Y Honda Makoto M Högl Birgit B Ton Thanh G N TG Montplaisir Jacques J Bourgin Patrice P Kemlink David D Huang Yu-Shu YS Warby Simon S Einen Mali M Eshragh Jasmin L JL Miyagawa Taku T Desautels Alex A Ruppert Elisabeth E Hesla Per Egil PE Poli Francesca F Pizza Fabio F Frauscher Birgit B Jeong Jong-Hyun JH Lee Sung-Pil SP Strohl Kingman P KP Longstreth William T WT Kvale Mark M Dobrovolna Marie M Ohayon Maurice M MM Nepom Gerald T GT Wichmann H-Erich HE Rouleau Guy A GA Gieger Christian C Levinson Douglas F DF Gejman Pablo V PV Meitinger Thomas T Peppard Paul P Young Terry T Jennum Poul P Steinman Lawrence L Tokunaga Katsushi K Kwok Pui-Yan PY Risch Neil N Hallmayer Joachim J Mignot Emmanuel E
Nature genetics 20101219 1
Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease. We here report genome-wide association analyses for narcolepsy with replication and fine mapping across three ethnic groups (3,406 individuals of European ancestry, 2,414 Asians and 302 African Americans). We identify a SNP in the 3' untranslated region of P2RY11, the purinergic receptor subtype P2Y₁₁ gene, which is associated with narcolepsy (rs2305795, combined P = 6.1 × 10⁻¹⁰, odds ratio = 1.28, ...[more]
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