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Common variants at 11p13 are associated with susceptibility to tuberculosis.

ABSTRACT: After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

SUBMITTER: Thye T

PROVIDER: S-EPMC3427019 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Common variants at 11p13 are associated with susceptibility to tuberculosis.

Thye Thorsten T Owusu-Dabo Ellis E Vannberg Fredrik O FO van Crevel Reinout R Curtis James J Sahiratmadja Edhyana E Balabanova Yanina Y Ehmen Christa C Muntau Birgit B Ruge Gerd G Sievertsen Jürgen J Gyapong John J Nikolayevskyy Vladyslav V Hill Philip C PC Sirugo Giorgio G Drobniewski Francis F van de Vosse Esther E Newport Melanie M Alisjahbana Bachti B Nejentsev Sergey S Ottenhoff Tom H M TH Hill Adrian V S AV Horstmann Rolf D RD Meyer Christian G CG

Nature genetics 20120205 3

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11). ...[more]

PMID: 22306650

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