Unknown

Dataset Information

0

Evaluation of Diarylureas for Activity Against Plasmodium falciparum.


ABSTRACT: A library of diarylurea IGFR inhibitors was screened for activity against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. The 4-aminoquinaldine-derived diarylureas displayed promising antimalarial potency. Further exploration of the B ring of 4-aminoquinaldinyl ureas allowed identification of several quinaldin-4-yl ureas 4{13, 39} and 4{13, 58} sufficiently potent against both 3D7 and K1 strains to qualify as bone fide leads.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3019604 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4289231 | biostudies-literature
| S-EPMC3136263 | biostudies-literature
| S-EPMC3101419 | biostudies-literature
| S-EPMC6099641 | biostudies-literature
| S-EPMC5683671 | biostudies-literature
| S-EPMC8308784 | biostudies-literature
| S-EPMC4945415 | biostudies-literature
| S-EPMC6039313 | biostudies-literature
| S-EPMC6540015 | biostudies-literature
| S-EPMC7318029 | biostudies-literature