Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages.
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ABSTRACT:
SUBMITTER: Vanheer LN
PROVIDER: S-EPMC7318029 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages.
Vanheer Leen N LN Zhang Hao H Lin Gang G Kafsack Björn F C BFC
Antimicrobial agents and chemotherapy 20200623 7
Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new antimalarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of <i>Plasmodium falciparum</i> We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM. ...[more]
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