Ontology highlight
ABSTRACT:
SUBMITTER: Menzel TM
PROVIDER: S-EPMC3019648 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Menzel Thomas M TM Tischer Maximilian M François Patrice P Nickel Joachim J Schrenzel Jacques J Bruhn Heike H Albrecht Annette A Lehmann Leane L Holzgrabe Ulrike U Ohlsen Knut K
Antimicrobial agents and chemotherapy 20101011 1
Screening of various bisquaternary bisnaphthalimides against a variety of human pathogens revealed one compound, designated MT02, with strong inhibitory effects against Gram-positive bacteria. The MICs ranged from 0.31 μg/ml against community-acquired methicillin-resistant Staphylococcus aureus (MRSA) lineage USA300 to 20 μg/ml against Streptococcus pneumoniae. Radioactive whole-cell labeling experiments indicated a strong impact of MT02 on bacterial DNA replication. DNA microarray studies gener ...[more]