Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi T
PROVIDER: S-EPMC3020002 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Journal of virology 20101110 2
Tetherin, also known as BST-2/CD317/HM1.24, is an antiviral cellular protein that inhibits the release of HIV-1 particles from infected cells. HIV-1 viral protein U (Vpu) is a specific antagonist of human tetherin that might contribute to the high virulence of HIV-1. In this study, we show that three amino acid residues (I34, L37, and L41) in the transmembrane (TM) domain of human tetherin are critical for the interaction with Vpu by using a live cell-based assay. We also found that the conserva ...[more]