Ontology highlight
ABSTRACT:
SUBMITTER: Iwami S
PROVIDER: S-EPMC4505337 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Scientific reports 20150717
Among the four groups of HIV-1 (M, N, O, and P), HIV-1M alone is pandemic and has rapidly expanded across the world. However, why HIV-1M has caused a devastating pandemic while the other groups remain contained is unclear. Interestingly, only HIV-1M Vpu, a viral protein, can robustly counteract human tetherin, which tethers budding virions. Therefore, we hypothesize that this property of HIV-1M Vpu facilitates human-to-human viral transmission. Adopting a multilayered experimental-mathematical a ...[more]