DNA double-strand break repair and the evolution of intron density.
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ABSTRACT:
SUBMITTER: Farlow A
PROVIDER: S-EPMC3020277 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
DNA double-strand break repair and the evolution of intron density.
Farlow Ashley A Meduri Eshwar E Schlötterer Christian C
Trends in genetics : TIG 20101122 1
The density of introns is both an important feature of genome architecture and a highly variable trait across eukaryotes. This heterogeneity has posed an evolutionary puzzle for the last 30 years. Recent evidence is consistent with novel introns being the outcome of the error-prone repair of DNA double-stranded breaks (DSBs) via non-homologous end joining (NHEJ). Here we suggest that deletion of pre-existing introns could occur via the same pathway. We propose a novel framework in which species- ...[more]
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