The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms.
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ABSTRACT:
SUBMITTER: Crawford H
PROVIDER: S-EPMC3020512 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms.
Crawford Hayley H Matthews Philippa C PC Schaefer Malinda M Carlson Jonathan M JM Leslie Alasdair A Kilembe William W Allen Susan S Ndung'u Thumbi T Heckerman David D Hunter Eric E Goulder Philip J R PJ
Journal of virology 20101124 3
One proposed HIV vaccine strategy is to induce Gag-specific CD8(+) T-cell responses that can corner the virus, through fitness cost of viral escape and unavailability of compensatory mutations. We show here that the most variable capsid residues principally comprise escape mutants driven by protective alleles HLA-B*57, -5801, and -8101 and covarying HLA-independent polymorphisms that arise in conjunction with these escape mutations. These covarying polymorphisms are potentially compensatory and ...[more]
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