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Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides.

ABSTRACT: The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron-poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and solvent is required for achieving best results.

SUBMITTER: Nadres ET

PROVIDER: S-EPMC3021639 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides.

Nadres Enrico T ET Lazareva Anna A Daugulis Olafs O

The Journal of organic chemistry 20101230 2

The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron-poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and solvent is required for achieving best results. ...[more]

PMID: 21192652

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