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Palladium-catalyzed ?-arylation of aryl acetic acid derivatives via dienolate intermediates with aryl chlorides and bromides.

ABSTRACT: To date, examples of ?-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed ?-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed ?-arylation of styryl acetic acids is also described.

SUBMITTER: Sha SC

PROVIDER: S-EPMC4610326 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Palladium-catalyzed α-arylation of aryl acetic acid derivatives via dienolate intermediates with aryl chlorides and bromides.

Sha Sheng-Chun SC Zhang Jiadi J Walsh Patrick J PJ

Organic letters 20150112 3

To date, examples of α-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed γ-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed α-arylation of styryl acetic acids is also described. ...[more]

PMID: 25582024

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