Ontology highlight
ABSTRACT:
SUBMITTER: Miyamoto Y
PROVIDER: S-EPMC3022026 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Miyamoto Yuji Y Kitamura Noriaki N Nakamura Yasuyuki Y Futamura Manabu M Miyamoto Takafumi T Yoshida Masaki M Ono Masaya M Ichinose Shizuko S Arakawa Hirofumi H
PloS one 20110117 1
The accumulation of unhealthy mitochondria results in mitochondrial dysfunction, which has been implicated in aging, cancer, and a variety of degenerative diseases. However, the mechanism by which mitochondrial quality is regulated remains unclear. Here, we show that Mieap, a novel p53-inducible protein, induces intramitochondrial lysosome-like organella that plays a critical role in mitochondrial quality control. Mieap expression is directly regulated by p53 and is frequently lost in human canc ...[more]