Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts.
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ABSTRACT:
SUBMITTER: Qiu K
PROVIDER: S-EPMC9314359 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
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Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts.
Qiu Kangqiang K Zou Weiwei W Fang Hongbao H Hao Mingang M Mehta Kritika K Tian Zhiqi Z Guan Jun-Lin JL Zhang Kai K Huang Taosheng T Diao Jiajie J
Nature communications 20220725 1
Mitochondria are highly dynamic organelles whose fragmentation by fission is critical to their functional integrity and cellular homeostasis. Here, we develop a method via optogenetic control of mitochondria-lysosome contacts (MLCs) to induce mitochondrial fission with spatiotemporal accuracy. MLCs can be achieved by blue-light-induced association of mitochondria and lysosomes through various photoactivatable dimerizers. Real-time optogenetic induction of mitochondrial fission is tracked in livi ...[more]
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