Ontology highlight
ABSTRACT:
SUBMITTER: Lima MA
PROVIDER: S-EPMC3022730 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Lima Marcelo A MA Rudd Timothy R TR de Farias Eduardo H C EH Ebner Lyvia F LF Gesteira Tarsis F TF de Souza Lauro M LM Mendes Aline A Córdula Carolina R CR Martins João R M JR Hoppensteadt Debra D Fareed Jawed J Sassaki Guilherme L GL Yates Edwin A EA Tersariol Ivarne L S IL Nader Helena B HB
PloS one 20110118 1
The year 2007 was marked by widespread adverse clinical responses to heparin use, leading to a global recall of potentially affected heparin batches in 2008. Several analytical methods have since been developed to detect impurities in heparin preparations; however, many are costly and dependent on instrumentation with only limited accessibility. A method based on a simple UV-scanning assay, combined with principal component analysis (PCA), was developed to detect impurities, such as glycosaminog ...[more]