Ontology highlight
ABSTRACT:
SUBMITTER: Beloueche-Babari M
PROVIDER: S-EPMC5669455 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Beloueche-Babari Mounia M Wantuch Slawomir S Casals Galobart Teresa T Koniordou Markella M Parkes Harold G HG Arunan Vaitha V Chung Yuen-Li YL Eykyn Thomas R TR Smith Paul D PD Leach Martin O MO
Cancer research 20170918 21
Monocarboxylate transporters (MCT) modulate tumor cell metabolism and offer promising therapeutic targets for cancer treatment. Understanding the impact of MCT blockade on tumor cell metabolism may help develop combination strategies or identify pharmacodynamic biomarkers to support the clinical development of MCT inhibitors now in clinical trials. In this study, we assessed the impact of the MCT1 inhibitor AZD3965 on cancer cell metabolism <i>in vitro</i> and <i>in vivo</i> Exposing human lymph ...[more]