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Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.


ABSTRACT: BACKGROUND:The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations. METHODS:We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese. RESULTS:Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese. CONCLUSION:The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC3022841 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.

Zhang Wen W   Chen Xiaogang X   Gong Wei W   Tang Jinsong J   Tan Liwen L   Guo Hao H   Yao Yong-Gang YG  

Behavioral and brain functions : BBF 20101229


<h4>Background</h4>The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.<h4>Methods</h4>We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two r  ...[more]

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