Ontology highlight
ABSTRACT:
SUBMITTER: Guan F
PROVIDER: S-EPMC4530443 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Guan Fanglin F Li Lu L Qiao Chuchu C Chen Gang G Yan Tinglin T Li Tao T Zhang Tianxiao T Liu Xinshe X
Scientific reports 20150810
The heritability of schizophrenia (SCZ) has been estimated to be as high as 80%, suggesting that genetic factors may play an important role in the etiology of SCZ. Cav1.2 encoded by CACNA1C and Cav1.3 encoded by CACNA1D are dominant calcium channel-forming subunits of L-type Voltage-dependent Ca(2+) channels, expressed in many types of neurons. The CACNA1C has been consistently found to be a risk gene for SCZ, but it is unknown for CACNA1D. To investigate the association of CACNA1D with SCZ, we ...[more]