Ontology highlight
ABSTRACT:
SUBMITTER: Lipscomb MW
PROVIDER: S-EPMC3023581 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Lipscomb Michael W MW Taylor Jennifer L JL Goldbach Cristina J CJ Watkins Simon C SC Wesa Amy K AK Storkus Walter J WJ
European journal of immunology 20100201 2
Tolerogenic DC and suppressive Foxp3(+) Treg play important roles in preventing autoimmunity and allograft rejection. We report that (adenovirus mediated) ectopic expression of Foxp3 in human DC (i.e. DC.Foxp3) yields an APC that severely limits T-cell proliferation and type-1 immune responses from the naïve, but not memory, pool of responder T cells in vitro. In marked contrast, the frequencies of type-2 and Treg responses were dramatically increased after stimulation of naïve T cells with DC.F ...[more]