Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans.
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ABSTRACT:
SUBMITTER: King KY
PROVIDER: S-EPMC3025014 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans.
King Katherine Y KY Lew Justin D JD Ha Ngan P NP Lin Jeffery S JS Ma Xin X Graviss Edward A EA Goodell Margaret A MA
PloS one 20110121 1
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds rati ...[more]
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