Ontology highlight
ABSTRACT:
SUBMITTER: Simpson DS
PROVIDER: S-EPMC3025038 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Simpson Denise S DS Lovell Kimberly M KM Lozama Anthony A Han Nina N Day Victor W VW Dersch Christina M CM Rothman Richard B RB Prisinzano Thomas E TE
Organic & biomolecular chemistry 20090714 18
Further synthetic modification of the furan ring of salvinorin A (1), the major active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. A computational study has predicted 1 to be a reproductive toxicant in mammals and is suggestive that use of 1 may be associated with adverse effects. We report in this study that piperidine 21 and thiomorpholine 23 have been identified as selective partial agonists at kappa opioid receptors ...[more]