Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B.
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ABSTRACT:
SUBMITTER: Cho NJ
PROVIDER: S-EPMC3025298 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B.
Cho Nam-Joon NJ Dvory-Sobol Hadas H Lee Choongho C Cho Sang-Joon SJ Bryson Paul P Masek Marilyn M Elazar Menashe M Frank Curtis W CW Glenn Jeffrey S JS
Science translational medicine 20100101 15
New classes of drugs are needed to combat hepatitis C virus (HCV), an important worldwide cause of liver disease. We describe an activity of a key domain, an amphipathic helix we termed 4BAH2, within a specific HCV nonstructural protein, NS4B. In addition to its proposed role in viral replication, we validate 4BAH2 as essential for HCV genome replication and identify first-generation small-molecule inhibitors of 4BAH2 that specifically prevent HCV replication within cells. Mechanistic studies re ...[more]
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