Ontology highlight
ABSTRACT:
SUBMITTER: Rewitz KF
PROVIDER: S-EPMC3025487 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Rewitz Kim F KF Yamanaka Naoki N O'Connor Michael B MB
Developmental cell 20101201 6
Steroid hormones are systemic signaling molecules that regulate juvenile-adult transitions in both insects and mammals. In insects, pulses of the steroid hormone 20-hydroxyecdysone (20E) are generated by increased biosynthesis followed by inactivation/clearance. Although mechanisms that control 20E synthesis have received considerable recent attention, the physiological significance of 20E inactivation remains largely unknown. We show that the cytochrome P450 Cyp18a1 lowers 20E titer during the ...[more]