Ontology highlight
ABSTRACT:
SUBMITTER: Okamoto N
PROVIDER: S-EPMC6219898 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Okamoto Naoki N Viswanatha Raghuvir R Bittar Riyan R Li Zhongchi Z Haga-Yamanaka Sachiko S Perrimon Norbert N Yamanaka Naoki N
Developmental cell 20181004 3
Steroid hormones are a group of lipophilic hormones that are believed to enter cells by simple diffusion to regulate diverse physiological processes through intracellular nuclear receptors. Here, we challenge this model in Drosophila by demonstrating that Ecdysone Importer (EcI), a membrane transporter identified from two independent genetic screens, is involved in cellular uptake of the steroid hormone ecdysone. EcI encodes an organic anion transporting polypeptide of the evolutionarily conserv ...[more]