Ontology highlight
ABSTRACT:
SUBMITTER: Casas E
PROVIDER: S-EPMC3025803 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Cancer research 20110101 1
To metastasize, carcinoma cells must attenuate cell-cell adhesion to disseminate into distant organs. A group of transcription factors, including Twist1, Snail1, Snail2, ZEB1, and ZEB2, have been shown to induce epithelial mesenchymal transition (EMT), thus promoting tumor dissemination. However, it is unknown whether these transcription factors function independently or coordinately to activate the EMT program. Here we report that direct induction of Snail2 is essential for Twist1 to induce EMT ...[more]