Ontology highlight
ABSTRACT:
SUBMITTER: Jackstadt R
PROVIDER: S-EPMC3698521 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Jackstadt Rene R Röh Simone S Neumann Jens J Jung Peter P Hoffmann Reinhard R Horst David D Berens Christian C Bornkamm Georg W GW Kirchner Thomas T Menssen Antje A Hermeking Heiko H
The Journal of experimental medicine 20130610 7
The basic helix-loop-helix transcription factor AP4/TFAP4/AP-4 is encoded by a c-MYC target gene and displays up-regulation concomitantly with c-MYC in colorectal cancer (CRC) and numerous other tumor types. Here a genome-wide characterization of AP4 DNA binding and mRNA expression was performed using a combination of microarray, genome-wide chromatin immunoprecipitation, next-generation sequencing, and bioinformatic analyses. Thereby, hundreds of induced and repressed AP4 target genes were iden ...[more]