Ontology highlight
ABSTRACT:
SUBMITTER: Petrella S
PROVIDER: S-EPMC3025910 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Petrella Stéphanie S Gelus-Ziental Nathalie N Maudry Arnaud A Laurans Caroline C Boudjelloul Rachid R Sougakoff Wladimir W
PloS one 20110124 1
Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has been determined, showing significant differences in the substrate binding cavity when compared to the pyrazinamidases from Pyrococcus horikoshii and Acinetobacter baumanii. In M. tuberculosis, this region was found to hold a Fe(2+) ion coordinated by one aspartate and three histidines, one of them corresponding to His57 wh ...[more]