Ontology highlight
ABSTRACT:
SUBMITTER: Pedroso DC
PROVIDER: S-EPMC3026015 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Pedroso Dora C S DC Tellechea Ana A Moura Liane L Fidalgo-Carvalho Isabel I Duarte João J Carvalho Eugénia E Carvalho Eugénia E Ferreira Lino L
PloS one 20110124 1
In this study, we developed a methodology to improve the survival, vascular differentiation and regenerative potential of umbilical cord blood (UCB)-derived hematopoietic stem cells (CD34(+) cells), by co-culturing the stem cells in a 3D fibrin gel with CD34(+)-derived endothelial cells (ECs). ECs differentiated from CD34(+) cells appear to have superior angiogenic properties to fully differentiated ECs, such as human umbilical vein endothelial cells (HUVECs). Our results indicate that the pro-s ...[more]