Ontology highlight
ABSTRACT:
SUBMITTER: Birse RT
PROVIDER: S-EPMC3026640 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Birse Ryan T RT Choi Joan J Reardon Kathryn K Rodriguez Jessica J Graham Suzanne S Diop Soda S Ocorr Karen K Bodmer Rolf R Oldham Sean S
Cell metabolism 20101101 5
High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and cardiovascular disease, but the underlying genetic mechanisms are poorly understood. Here, we use Drosophila to test the hypothesis that HFD-induced obesity and associated cardiac complications have early evolutionary origins involving nutrient-sensing signal transduction pathways. We find that HFD-fed flies exhibit increased triglyceride (TG) fat and alterations in insulin/glucose homeostasis, similar to mammalian respon ...[more]