Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3026657 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Wang Xiaodan X Vatamaniuk Marko Z MZ Roneker Carol A CA Pepper Matthew P MP Hu Liangbiao G LG Simmons Rebecca A RA Lei Xin Gen XG
Antioxidants & redox signaling 20100929 3
Metabolic subtlety and clinical relevance of different forms of reactive oxygen species in diabetes remain unclear. Using single knockout of Cu,Zn-superoxide dismutase (SOD1(-/-)) or Se-glutathione peroxidase-1 (GPX1(-/-)) and their double-knockout (DKO) mouse models, we determined if elevating endogenously-derived superoxide and hydroperoxide exerted distinct impacts and mechanisms on body glucose homeostasis. Whereas the three knockout groups displayed decreased plasma insulin concentrations a ...[more]