Ontology highlight
ABSTRACT:
SUBMITTER: Wood LM
PROVIDER: S-EPMC3027683 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Wood Laurence M LM Sankar Surendran S Reed Ryan E RE Haas Arthur L AL Liu Leroy F LF McKinnon Peter P Desai Shyamal D SD
PloS one 20110126 1
Ataxia Telangiectasia (A-T) is an inherited immunodeficiency disorder wherein mutation of the ATM kinase is responsible for the A-T pathogenesis. Although the precise role of ATM in A-T pathogenesis is still unclear, its function in responding to DNA damage has been well established. Here we demonstrate that in addition to its role in DNA repair, ATM also regulates proteasome-mediated protein turnover through suppression of the ISG15 pathway. This conclusion is based on three major pieces of evi ...[more]