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Asymmetric synthesis of tertiary benzylic alcohols.

ABSTRACT: Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.

SUBMITTER: Antczak MI

PROVIDER: S-EPMC3028934 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of tertiary benzylic alcohols.

Antczak Monika I MI Cai Feng F Ready Joseph M JM

Organic letters 20101213 2

Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups. ...[more]

PMID: 21142190

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