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Asymmetric Synthesis of ?-Amino Alcohols by Copper-Catalyzed Hydroamination.

ABSTRACT: Asymmetric synthesis of ?-amino alcohols from unprotected allylic alcohols by a copper-catalyzed hydroamination strategy has been developed. Using easily accessible starting materials, a range of chiral 1,3-amino alcohols were prepared with excellent regio- and enantioselectivity. Further, this protocol provided an efficient one-step method for the enantioselective synthesis of ?-amino alcohols in an intermolecular manner.

SUBMITTER: Ichikawa S

PROVIDER: S-EPMC6956864 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination.

Ichikawa Saki S Buchwald Stephen L SL

Organic letters 20191018 21

Asymmetric synthesis of γ-amino alcohols from unprotected allylic alcohols by a copper-catalyzed hydroamination strategy has been developed. Using easily accessible starting materials, a range of chiral 1,3-amino alcohols were prepared with excellent regio- and enantioselectivity. Further, this protocol provided an efficient one-step method for the enantioselective synthesis of γ-amino alcohols in an intermolecular manner. ...[more]

PMID: 31625750

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