Ontology highlight
ABSTRACT:
SUBMITTER: Herant M
PROVIDER: S-EPMC3029235 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Herant Marc M Lee Cheng-Yuk CY Dembo Micah M Heinrich Volkmar V
PLoS computational biology 20110127 1
Encounters between human neutrophils and zymosan elicit an initially protrusive cell response that is distinct from the thin lamella embracing antibody-coated targets. Recent experiments have led us to hypothesize that this behavior has its mechanistic roots in the modulation of interactions between membrane and cytoskeleton. To test and refine this hypothesis, we confront our experimental results with predictions of a computer model of leukocyte mechanical behavior, and establish the minimum se ...[more]