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Bub1-mediated adaptation of the spindle checkpoint.


ABSTRACT: During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules. The spindle checkpoint is deactivated as chromosomes start moving toward the spindles in anaphase, but the mechanisms by which this deactivation and adaptation to prolonged mitotic arrest occur remain obscure. Our results strongly suggest that Cdc28-mediated phosphorylation of Bub1 at T566 plays an important role for the degradation of Bub1 in anaphase, and the phosphorylation is required for adaptation of the spindle checkpoint to prolonged mitotic arrest.

SUBMITTER: Goto GH 

PROVIDER: S-EPMC3029250 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Bub1-mediated adaptation of the spindle checkpoint.

Goto Greicy H GH   Mishra Ashutosh A   Abdulle Rashid R   Slaughter Clive A CA   Kitagawa Katsumi K  

PLoS genetics 20110127 1


During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules. The spindle checkpoint is deactivated as chromosomes start moving toward the spindles in anaphase, but the mechanisms by which this deactivation and adaptation to prolonged mitotic arrest occur remain obscure. Our results strongly suggest that Cdc28-  ...[more]

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