Ontology highlight
ABSTRACT:
SUBMITTER: Goto GH
PROVIDER: S-EPMC3029250 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Goto Greicy H GH Mishra Ashutosh A Abdulle Rashid R Slaughter Clive A CA Kitagawa Katsumi K
PLoS genetics 20110127 1
During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules. The spindle checkpoint is deactivated as chromosomes start moving toward the spindles in anaphase, but the mechanisms by which this deactivation and adaptation to prolonged mitotic arrest occur remain obscure. Our results strongly suggest that Cdc28- ...[more]