Ontology highlight
ABSTRACT:
SUBMITTER: Krenn V
PROVIDER: S-EPMC3283998 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Krenn Veronica V Wehenkel Annemarie A Li Xiaozheng X Santaguida Stefano S Musacchio Andrea A
The Journal of cell biology 20120213 4
The function of the essential checkpoint kinases Bub1 and BubR1 requires their recruitment to mitotic kinetochores. Kinetochore recruitment of Bub1 and BubR1 is proposed to rely on the interaction of the tetratricopeptide repeats (TPRs) of Bub1 and BubR1 with two KI motifs in the outer kinetochore protein Knl1. We determined the crystal structure of the Bub1 TPRs in complex with the cognate Knl1 KI motif and compared it with the structure of the equivalent BubR1TPR-KI motif complex. The interact ...[more]