Ontology highlight
ABSTRACT:
SUBMITTER: Maag D
PROVIDER: S-EPMC3029688 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Maag David D Maxwell Micah J MJ Hardesty Douglas A DA Boucher Katie L KL Choudhari Namrata N Hanno Adam G AG Ma Jenny F JF Snowman Adele S AS Pietropaoli Joseph W JW Xu Risheng R Storm Phillip B PB Saiardi Adolfo A Snyder Solomon H SH Resnick Adam C AC
Proceedings of the National Academy of Sciences of the United States of America 20110110 4
The second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP(3)), formed by the p110 family of PI3-kinases, promotes cellular growth, proliferation, and survival, in large part by activating the protein kinase Akt/PKB. We show that inositol polyphosphate multikinase (IPMK) physiologically generates PIP(3) as well as water soluble inositol phosphates. IPMK deletion reduces growth factor-elicited Akt signaling and cell proliferation caused uniquely by loss of its PI3-kinase activity. Inhib ...[more]