Ontology highlight
ABSTRACT:
SUBMITTER: Zheng L
PROVIDER: S-EPMC3029719 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Zheng Le L Stathopulos Peter B PB Schindl Rainer R Li Guang-Yao GY Romanin Christoph C Ikura Mitsuhiko M
Proceedings of the National Academy of Sciences of the United States of America 20110107 4
Stromal interaction molecules (STIM)s function as endoplasmic reticulum calcium (Ca(2+)) sensors that differentially regulate plasma membrane Ca(2+) release activated Ca(2+) channels in various cells. To probe the structural basis for the functional differences between STIM1 and STIM2 we engineered a series of EF-hand and sterile α motif (SAM) domain (EF-SAM) chimeras, demonstrating that the STIM1 Ca(2+)-binding EF-hand and the STIM2 SAM domain are major contributors to the autoinhibition of oli ...[more]