Ontology highlight
ABSTRACT:
SUBMITTER: Rubelt F
PROVIDER: S-EPMC5191574 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Rubelt Florian F Bolen Christopher R CR McGuire Helen M HM Vander Heiden Jason A JA Gadala-Maria Daniel D Levin Mikhail M Euskirchen Ghia M GM Mamedov Murad R MR Swan Gary E GE Dekker Cornelia L CL Cowell Lindsay G LG Kleinstein Steven H SH Davis Mark M MM
Nature communications 20160323
The adaptive immune system's capability to protect the body requires a highly diverse lymphocyte antigen receptor repertoire. However, the influence of individual genetic and epigenetic differences on these repertoires is not typically measured. By leveraging the unique characteristics of B, CD4(+) T and CD8(+) T-lymphocyte subsets from monozygotic twins, we quantify the impact of heritable factors on both the V(D)J recombination process and on thymic selection. We show that the resulting biases ...[more]