Ontology highlight
ABSTRACT:
SUBMITTER: Chi CN
PROVIDER: S-EPMC3030364 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Chi Celestine N CN Bach Anders A Engström Åke Å Strømgaard Kristian K Lundström Patrik P Ferguson Neil N Jemth Per P
The Journal of biological chemistry 20101127 5
The E6 protein of human papillomavirus (HPV) exhibits complex interaction patterns with several host proteins, and their roles in HPV-mediated oncogenesis have proved challenging to study. Here we use several biophysical techniques to explore the binding of E6 to the three PDZ domains of the tumor suppressor protein synapse-associated protein 97 (SAP97). All of the potential binding sites in SAP97 bind E6 with micromolar affinity. The dissociation rate constants govern the different affinities o ...[more]