Ontology highlight
ABSTRACT:
SUBMITTER: Egan DF
PROVIDER: S-EPMC3030664 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20101223 6016
Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and environmental stress. In a screen for conserved substrates of AMPK, we identified ULK1 and ULK2, mammalian orthologs of the yeast protein kinase Atg1, which is required for autophagy. Genetic analysis of AMPK or ULK1 in mammalian liver and Caenorhabditis elegans revealed a requirement for these kinases in autophagy. In mammals, loss of AMPK ...[more]