Ontology highlight
ABSTRACT:
SUBMITTER: Sheffield ME
PROVIDER: S-EPMC3030701 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Sheffield Mark E J ME Best Tyler K TK Mensh Brett D BD Kath William L WL Spruston Nelson N
Nature neuroscience 20101208 2
The conventional view of neurons is that synaptic inputs are integrated on a timescale of milliseconds to seconds in the dendrites, with action potential initiation occurring in the axon initial segment. We found a much slower form of integration that leads to action potential initiation in the distal axon, well beyond the initial segment. In a subset of rodent hippocampal and neocortical interneurons, hundreds of spikes, evoked over minutes, resulted in persistent firing that lasted for a simil ...[more]