Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC3031169 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Wang Junling J Han Xuemei X Saha Sougata S Xu Tao T Rai Reena R Zhang Fangliang F Wolf Yuri I YI Wolfson Alexey A Yates John R JR Kashina Anna A
Chemistry & biology 20110101 1
Posttranslational arginylation mediated by arginyl transferase (ATE1) plays an important role in cardiovascular development, cell motility, and regulation of cytoskeleton and metabolic enzymes. This protein modification was discovered decades ago, however, the arginylation reaction and the functioning of ATE1 remained poorly understood because of the lack of good biochemical models. Here, we report the development of an in vitro arginylation system, in which ATE1 function and molecular requireme ...[more]