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Resting state functional connectivity within the cingulate cortex jointly predicts agreeableness and stressor-evoked cardiovascular reactivity.

ABSTRACT: Exaggerated cardiovascular reactivity to stress is a risk factor for cardiovascular disease. Further, individual differences in stressor-evoked cardiovascular reactivity covary with the functionality of corticolimbic brain systems, particularly areas of the cingulate cortex. What remains unclear, however, is how individual differences in personality traits interact with cingulate functionality in the prediction of stressor-evoked cardiovascular reactivity. Accordingly, we tested the associations between (i) a particular personality trait, Agreeableness, which is associated with emotional reactions to conflict, (ii) resting state functional connectivity within the cingulate cortex, and (iii) stressor-evoked blood pressure (BP) reactivity. Participants (N=39, 19 men, aged 20-37 years) completed a resting functional connectivity MRI protocol, followed by two standardized stressor tasks that engaged conflict processing and evoked BP reactivity. Agreeableness covaried positively with BP reactivity across individuals. Moreover, connectivity analyses demonstrated that a more positive functional connectivity between the posterior cingulate (BA31) and the perigenual anterior cingulate (BA32) covaried positively with Agreeableness and with BP reactivity. Finally, statistical mediation analyses demonstrated that BA31-BA32 connectivity mediated the covariation between Agreeableness and BP reactivity. Functional connectivity within the cingulate appears to link Agreeableness and a risk factor for cardiovascular disease, stressor-evoked BP reactivity.

SUBMITTER: Ryan JP

PROVIDER: S-EPMC3031759 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Resting state functional connectivity within the cingulate cortex jointly predicts agreeableness and stressor-evoked cardiovascular reactivity.

Ryan John P JP Sheu Lei K LK Gianaros Peter J PJ

NeuroImage 20101202 1

Exaggerated cardiovascular reactivity to stress is a risk factor for cardiovascular disease. Further, individual differences in stressor-evoked cardiovascular reactivity covary with the functionality of corticolimbic brain systems, particularly areas of the cingulate cortex. What remains unclear, however, is how individual differences in personality traits interact with cingulate functionality in the prediction of stressor-evoked cardiovascular reactivity. Accordingly, we tested the associations ...[more]

PMID: 21130172

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Project description:Although adolescence is a period in which developmental changes occur in brain connectivity, personality formation, and peer interaction, few studies have examined the neural correlates of personality dimensions related to social behavior within adolescent samples. The current study aims to investigate whether adolescents' brain functional connectivity is associated with extraversion and agreeableness, personality dimensions linked to peer acceptance, social network size, and friendship quality. Considering sex-variant neural maturation in adolescence, we also examined sex-specific associations between personality and functional connectivity. Using resting-state functional magnetic resonance imaging (fMRI) data from a community sample of 70 adolescents aged 12-15, we examined associations between self-reported extraversion and agreeableness and seed-to-whole brain connectivity with the amygdala as a seed region of interest. Then, using 415 brain regions that correspond to 8 major brain networks and subcortex, we explored neural connectivity within brain networks and across the whole-brain. We conducted group-level multiple regression analyses with the regressors of extraversion, agreeableness, and their interactions with sex. Results demonstrated that amygdala connectivity with the postcentral gyrus, middle temporal gyrus, and the temporal pole is positively associated with extraversion in girls and negatively associated with extraversion in boys. Agreeableness was positively associated with amygdala connectivity with the middle occipital cortex and superior parietal cortex, in the same direction for boys and girls. Results of the whole-brain connectivity analysis revealed that the connectivity of the postcentral gyrus, located in the dorsal attention network, with regions in default mode network (DMN), salience/ventral attention network, and control network (CON) was associated with extraversion, with most connections showing positive associations in girls and negative associations in boys. For agreeableness, results of the within-network connectivity analysis showed that connections within the limbic network were positively associated with agreeableness in boys while negatively associated with or not associated with agreeableness in girls. Results suggest that intrinsic functional connectivity may contribute to adolescents' individual differences in extraversion and agreeableness and highlights sex-specific neural connectivity patterns associated with the two personality dimensions. This study deepens our understanding of the neurobiological correlates of adolescent personality that may lead to different developmental trajectories of social experience.

Dataset Information

Resting state functional connectivity within the cingulate cortex jointly predicts agreeableness and stressor-evoked cardiovascular reactivity.

Publications

Resting state functional connectivity within the cingulate cortex jointly predicts agreeableness and stressor-evoked cardiovascular reactivity.

Similar Datasets

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