Ontology highlight
ABSTRACT:
SUBMITTER: Sikkink LA
PROVIDER: S-EPMC3032327 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Sikkink L A LA Ramirez-Alvarado M M
Cell death & disease 20101111
Light-chain amyloidosis (AL) is a devastating protein-misfolding disease characterized by abnormal proliferation of plasma cells in the bone marrow that secrete monoclonal immunoglobulin light chains that misfold and form amyloid fibrils, thus causing organ failure and death. Numerous reports on different protein-misfolding diseases show that soluble oligomeric species populated by amyloidogenic proteins can be quite toxic to cells. However, it is not well established whether the soluble immunog ...[more]