Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
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ABSTRACT:
SUBMITTER: Cummins NW
PROVIDER: S-EPMC3032328 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
Cell death & disease 20101111
The inevitable decline of CD4T cells in untreated infection with the Human immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell death. There is accumulating evidence that the accelerated apoptosis of CD4T cells in HIV infection is multifactorial, with direct viral cytotoxicity, signaling events triggered by viral proteins and aberrant immune activation adding to normal immune defense mechanisms to contribute to this phenomenon. Current antiviral treatment s ...[more]
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