The miR-17-92 microRNA cluster regulates multiple components of the TGF-? pathway in neuroblastoma.
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ABSTRACT:
SUBMITTER: Mestdagh P
PROVIDER: S-EPMC3032380 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma.
Mestdagh Pieter P Boström Anna-Karin AK Impens Francis F Fredlund Erik E Van Peer Gert G De Antonellis Pasqualino P von Stedingk Kristoffer K Ghesquière Bart B Schulte Stefanie S Dews Michael M Thomas-Tikhonenko Andrei A Schulte Johannes H JH Zollo Massimo M Schramm Alexander A Gevaert Kris K Axelson Håkan H Speleman Frank F Vandesompele Jo J
Molecular cell 20101201 5
The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains elusive. Using SILAC and quantitative mass spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma (NB) cells. Our results reveal cooperation between individual miR-17-92 miRNAs and implicate miR-17-92 in multiple hallmarks of cancer, including proliferation and cell adhesion. Most importantly, we show that miR-17-92 is a po ...[more]
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