Ontology highlight
ABSTRACT:
SUBMITTER: Ji M
PROVIDER: S-EPMC3181398 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Ji Ming M Rao Enyu E Ramachandrareddy Himabindu H Shen Yulei Y Jiang Chunsun C Chen Jianxiu J Hu Yiqiao Y Rizzino Angie A Chan Wing C WC Fu Kai K McKeithan Timothy W TW
The American journal of pathology 20110730 4
A cluster of six microRNAs (miRNAs), miR-17-92, is processed from the transcript of C13orf25, a gene amplified in some lymphomas and solid tumors. We find that levels of the miRNAs in the cluster do not vary entirely in parallel with each other or with the primary RNA in B-cell lines or normal cells, suggesting that processing or stability of the miRNAs is differentially regulated. Using luciferase reporter assays, we identified the region required for maximum promoter activity. Additional delet ...[more]